Brand Name NDC 00009027101

Depo-estradiol 5 Mg/ml Vial

NADAC pharmacy acquisition cost from CMS

NADAC Per Unit
$49.35
Pharmacy acquisition cost
Est. 30-Day Supply
$1,481
At NADAC cost (1/day)
Est. 90-Day Supply
$4,442
At NADAC cost (1/day)
Est. Retail Price / Unit
$66.62
~35% pharmacy markup
Est. Retail 30-Day
$1,999
Without insurance
Est. Annual Cost
$24,318
Retail, 1 unit/day

Understanding Drug Pricing

1
NADAC (shown above) — What the pharmacy pays the wholesaler for this drug. This is the most transparent baseline cost, published weekly by CMS.
2
Retail Price — Pharmacies add a dispensing fee ($2-$15) and markup (20-50%). This is what you pay without insurance or discount cards.
3
Insurance Copay — With insurance, you typically pay a flat copay ($5-$15 generic, $25-$50 brand) regardless of the NADAC cost.

Frequently Asked Questions

How much does Depo-estradiol cost?

The pharmacy acquisition cost (NADAC) for Depo-estradiol 5 Mg/ml Vial is $49.35 per unit. A 30-day supply at 1 unit per day costs approximately $1,481.

How much does Depo-estradiol cost without insurance?

Without insurance, expect to pay approximately $1,999 for a 30-day supply. Pharmacy discount programs (GoodRx, RxSaver, Cost Plus Drugs) and manufacturer coupons can reduce this significantly. Ask your doctor if a generic alternative is available — generics typically cost 80-85% less.

Is Depo-estradiol available as a generic?

Depo-estradiol is a brand name medication. Generic alternatives may be available. Ask your pharmacist about equivalent generics which can save 80-85%.

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