Brand Name NDC 58406001004
Enbrel 25 Mg/0.5 ML Syringe
NADAC pharmacy acquisition cost from CMS
NADAC Per Unit
$2076.23
Pharmacy acquisition cost
Est. 30-Day Supply
$62,287
At NADAC cost (1/day)
Est. 90-Day Supply
$186,861
At NADAC cost (1/day)
Est. Retail Price / Unit
$2802.91
~35% pharmacy markup
Est. Retail 30-Day
$84,087
Without insurance
Est. Annual Cost
$1,023,063
Retail, 1 unit/day
Understanding Drug Pricing
1
NADAC (shown above) — What the pharmacy pays the wholesaler for this drug.
This is the most transparent baseline cost, published weekly by CMS.
2
Retail Price — Pharmacies add a dispensing fee ($2-$15) and markup (20-50%).
This is what you pay without insurance or discount cards.
3
Insurance Copay — With insurance, you typically pay a flat copay
($5-$15 generic, $25-$50 brand) regardless of the NADAC cost.
Frequently Asked Questions
How much does Enbrel cost?
The pharmacy acquisition cost (NADAC) for Enbrel 25 Mg/0.5 ML Syringe is $2076.23 per unit. A 30-day supply at 1 unit per day costs approximately $62,287.
How much does Enbrel cost without insurance?
Without insurance, expect to pay approximately $84,087 for a 30-day supply. Pharmacy discount programs (GoodRx, RxSaver, Cost Plus Drugs) and manufacturer coupons can reduce this significantly. Ask your doctor if a generic alternative is available — generics typically cost 80-85% less.
Is Enbrel available as a generic?
Enbrel is a brand name medication. Generic alternatives may be available. Ask your pharmacist about equivalent generics which can save 80-85%.